The effects of mitochondrial transplantation in acetaminophen-induced liver toxicity in rats

Ulger O., Kubat G. B., Cicek Z., Celik E., ATALAY Ö., Suvay S., ...More

LIFE SCIENCES, vol.279, 2021 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 279
  • Publication Date: 2021
  • Doi Number: 10.1016/j.lfs.2021.119669
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Hacettepe University Affiliated: Yes

Abstract

Aims: Acetaminophen (APAP) toxicity is one of the leading causes of acute liver injury-related death and liver failure worldwide. In many studies, mitochondrial dysfunction has been identified as an important cause of damage in APAP toxicity. Therefore, our study aimed to investigate the possible effects of mitochondrial transplantation on liver damage due to APAP toxicity.