Acute lymphoblastic leukaemia in a child with systemic lupus erythematosus

Gokce M., Bulus D., Bilginer Y., Gumruk F., Besbas N., Cetin M.

LUPUS, vol.21, no.8, pp.910-913, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 8
  • Publication Date: 2012
  • Doi Number: 10.1177/0961203312436859
  • Journal Name: LUPUS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.910-913
  • Hacettepe University Affiliated: Yes

Abstract

Haematological involvement of systemic lupus erythematosus (SLE) - which ranges from the well-described haemolytic anaemia to macrophage activation syndrome - has a large impact on both morbidity and mortality. On the other hand, association between haematological malignities and SLE - in terms of pathophysiology and molecular genetics - is an obscure entity which has not been clarified evidently to date. Herein, we present a six-year-old female with the diagnosis of SLE who developed acute lymphoblastic leukaemia following a period of myelodysplasia. It could possibly be coincidental; however, persistent cytopenia, prominent dysplasia on bone marrow smears and azathioprine treatment may be considered as possible triggers for the development of leukaemia in the present case. Lupus (2012) 21, 910-913.