Multidrug resistance in patients undergoing resective epilepsy surgery is not associated with C3435T polymorphism in the ABCB1 (MDR1) gene

DERİCİOĞLU N., BABAOĞLU M. Ö., YAŞAR Ü., BAL I. B., BOZKURT A., SAYGI S.

EPILEPSY RESEARCH, cilt.80, sa.1, ss.42-46, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 80 Sayı: 1
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.eplepsyres.2008.03.004
  • Dergi Adı: EPILEPSY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.42-46
  • Anahtar Kelimeler: multidrug resistance, refractory epilepsy, epilepsy surgery, ABCB1 (MDR1) gene, C3435T polymorphism, REFRACTORY EPILEPSY, PHARMACORESISTANCE, TRANSPORTERS, EXPRESSION
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Purpose: The C3435T polymorphism in the gene coding for P-glycoprotein (ABCB1) has been correlated with drug resistance in patients with epilepsy. However, replication studies have revealed conflicting results and the reason for this is not clear. We investigated the frequency of C3435T polymorphism in epileptic Turkish patients who underwent resective epilepsy surgery and compared our results with healthy controls.