EPILEPSY RESEARCH, vol.80, no.1, pp.42-46, 2008 (Peer-Reviewed Journal)
Article / Article
Science Citation Index Expanded, Scopus
multidrug resistance, refractory epilepsy, epilepsy surgery, ABCB1 (MDR1) gene, C3435T polymorphism, REFRACTORY EPILEPSY, PHARMACORESISTANCE, TRANSPORTERS, EXPRESSION
Purpose: The C3435T polymorphism in the gene coding for P-glycoprotein (ABCB1) has been correlated with drug resistance in patients with epilepsy. However, replication studies have revealed conflicting results and the reason for this is not clear. We investigated the frequency of C3435T polymorphism in epileptic Turkish patients who underwent resective epilepsy surgery and compared our results with healthy controls.