Multidrug resistance in patients undergoing resective epilepsy surgery is not associated with C3435T polymorphism in the ABCB1 (MDR1) gene


DERİCİOĞLU N., BABAOĞLU M. Ö. , YAŞAR Ü., BAL I. B. , BOZKURT A., SAYGI S.

EPILEPSY RESEARCH, vol.80, no.1, pp.42-46, 2008 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 80 Issue: 1
  • Publication Date: 2008
  • Doi Number: 10.1016/j.eplepsyres.2008.03.004
  • Journal Name: EPILEPSY RESEARCH
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.42-46
  • Keywords: multidrug resistance, refractory epilepsy, epilepsy surgery, ABCB1 (MDR1) gene, C3435T polymorphism, REFRACTORY EPILEPSY, PHARMACORESISTANCE, TRANSPORTERS, EXPRESSION

Abstract

Purpose: The C3435T polymorphism in the gene coding for P-glycoprotein (ABCB1) has been correlated with drug resistance in patients with epilepsy. However, replication studies have revealed conflicting results and the reason for this is not clear. We investigated the frequency of C3435T polymorphism in epileptic Turkish patients who underwent resective epilepsy surgery and compared our results with healthy controls.