The role of BRD7 in embryo development and glucose metabolism

Kim Y., Hernandez M. A. S., Herrema H., DELİBAŞI T., Park S. W.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, cilt.20, sa.8, ss.1561-1570, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 8
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1111/jcmm.12907
  • Dergi Adı: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1561-1570
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Bromodomain-containing protein 7 (BRD7) is a member of bromodomain-containing protein family and its function has been implicated in several diseases. We have previously shown that BRD7 plays a role in metabolic processes. However, the effect of BRD7 deficiency in glucose metabolism and its role in in vivo have not been fully revealed. Here, we report the essential role of BRD7 during embryo development. Mice homozygous for BRD7 led to embryonic lethality at mid-gestation. Homozygous BRD7 knockout (KO) mice showed retardation in development, and eventually all BRD7 KO embryos died in utero prior to E16.5. Partial knockdown of Brd7 gene displayed mild changes in glucose metabolism.