Long-term survival in severe combined immune deficiency: The role of persistent maternal engraftment

Tezcan I., Ersoy F., Sanal O., Turul T., Uckan D., Balci S., ...Daha Fazla

JOURNAL OF PEDIATRICS, cilt.146, sa.1, ss.137-140, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 146 Sayı: 1
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.jpeds.2004.09.010
  • Dergi Adı: JOURNAL OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.137-140
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Two siblings with severe combined immune deficiency, one with maternal engraftment and detectable immunologic functions who was alive at the age of 8 years are presented. Both patients had the same. JAK3 gene mutation, suggesting that maternal engraftment may result in immune competence leading to long-term survival in patients with severe combined immune deficiency.