Synthesis and anticonvulsant activity of some new dioxolane derivatives

Ozkanli F., Guney A., Calis U., Uzbay T.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, cilt.53, sa.11, ss.758-762, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 53 Sayı: 11
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1055/s-0031-1299825
  • Dergi Adı: ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.758-762
  • Hacettepe Üniversitesi Adresli: Hayır

Özet

In this study, ten 2-acetylnaphthalene derivatives with a dioxolane structure were synthesized and screened for their anticonvulsant activities. Dioxolane derivatives were prepared by the reaction with appropriate ethanone, glycol and p-toluensulphonic acid. The structures of the compounds were elucidated by IR, H-1-NMR and elemental analysis. Anticonvulsant activities of the compounds were determined by maximal electroshock seizure (MES) test and subcutaneous metrazol (ScMet.) test. The rotarod toxicity test was used for the assessment of neurological deficits. According to the activity studies compound 6 was found neurotoxic, compounds, 1, 4, 5, 7-9 were found protective against MES and 7-10 were found protective against SeMet. Compounds 2 and 3 were found inactive.