DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol.42, no.6, pp.1008-1017, 2016 (Peer-Reviewed Journal)
Article / Article
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
Science Citation Index Expanded, Scopus
microencapsulation, Formulation development, taste masking, mirtazapine, orally disintegrating tablets, TASTE MASKING, PHARMACOKINETICS, PROFILE
Objective: Orally disintegrating tablets (ODTs) recently have gained much attention to fulfill the needs for pediatric, geriatric, and psychiatric patients with dysphagia. Aim of this study was to develop new ODT formulations containing mirtazapine, an antidepressant drug molecule having bitter taste, by using simple and inexpensive preparation methods such as coacervation, direct compression and to compare their characteristics with those of reference product (Remereon SolTab).