Formulation studies for mirtazapine orally disintegrating tablets


YILDIZ S., AYTEKİN E. , Yavuz B. , Pehlivan S. , UNLU N.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, cilt.42, ss.1008-1017, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 42 Konu: 6
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3109/03639045.2015.1104345
  • Dergi Adı: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
  • Sayfa Sayıları: ss.1008-1017

Özet

Objective: Orally disintegrating tablets (ODTs) recently have gained much attention to fulfill the needs for pediatric, geriatric, and psychiatric patients with dysphagia. Aim of this study was to develop new ODT formulations containing mirtazapine, an antidepressant drug molecule having bitter taste, by using simple and inexpensive preparation methods such as coacervation, direct compression and to compare their characteristics with those of reference product (Remereon SolTab).