Formulation studies for mirtazapine orally disintegrating tablets

YILDIZ S., AYTEKİN E., Yavuz B., Pehlivan S., UNLU N.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol.42, no.6, pp.1008-1017, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 6
  • Publication Date: 2016
  • Doi Number: 10.3109/03639045.2015.1104345
  • Journal Name: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1008-1017
  • Keywords: microencapsulation, Formulation development, taste masking, mirtazapine, orally disintegrating tablets, TASTE MASKING, PHARMACOKINETICS, PROFILE
  • Hacettepe University Affiliated: Yes

Abstract

Objective: Orally disintegrating tablets (ODTs) recently have gained much attention to fulfill the needs for pediatric, geriatric, and psychiatric patients with dysphagia. Aim of this study was to develop new ODT formulations containing mirtazapine, an antidepressant drug molecule having bitter taste, by using simple and inexpensive preparation methods such as coacervation, direct compression and to compare their characteristics with those of reference product (Remereon SolTab).