Klotho gene G395A and C1818T polymorphisms in acromegaly: Association with clinical presentation and comorbidities.


Helvaci N., Kabacam S., Dagdelen S., Lay İ., Karabulut E., Mut M., ...More

Clinical endocrinology, vol.94, no.4, pp.598-605, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 94 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.1111/cen.14380
  • Journal Name: Clinical endocrinology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, CAB Abstracts, EMBASE, Gender Studies Database, MEDLINE
  • Page Numbers: pp.598-605
  • Keywords: acromegaly, cancer, insulin&#8208, like growth factor&#8208, 1, Klotho, single nucleotide polymorphism, GROWTH-HORMONE, ALPHA-KLOTHO, SOLUBLE KLOTHO, CANCER RISK, OSTEOARTHRITIS, SUPPRESSOR, EXPRESSION
  • Hacettepe University Affiliated: Yes

Abstract

Background Klotho is a new identified anti-ageing gene with tumour suppressor activities. Current data suggest that there is a tight relationship between Klotho protein and growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis.