Characterization of serum N-glycome alterations in seasonal allergic rhinitis using MALDI-TOF-MS: A pilot study

YAMAN M. E., Avci I., Atila N. E., ATİLA A., Kayili H. M., SALİH B.

JOURNAL OF CARBOHYDRATE CHEMISTRY, cilt.40, ss.269-282, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1080/07328303.2021.2009502
  • Dergi Adı: JOURNAL OF CARBOHYDRATE CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, Veterinary Science Database
  • Sayfa Sayıları: ss.269-282
  • Anahtar Kelimeler: Glycomics, MALDI-TOF-MS, mass spectrometry, seasonal Allergic rhinitis (SAR), serum N-glycosylation, SIALIC ACIDS, GLYCOSYLATION, GLYCAN, CANCER, LYMPHOCYTES, HEALTH, TOOL
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Seasonal allergic rhinitis (SAR) is an inflammatory process. In this pilot study, matrix assisted laser desorption ionization-mass spectrometry (MALDI-MS)-based analyses were conducted to investigate the effects of SAR on serum N-glycome in a small dataset (n = 10 for both SAR patients and controls). It was detected that two N-glycan compositions (H6N5E2L1 and H6N5E1L2) were down-regulated in SAR patients. Additionally, five tri-antennary N-glycan traits, including both galactosylated and sialylated (A3GS and A3GL) and non-fucosylated (A3F0GE, A3F0GL, A3F0GS) ones, were decreased. Furthermore, three high-antennary and fucosylated N-glycan traits (A3F, A3EF and A4F) were increased in SAR patients compared to controls.