Evaluation of FSH, LH, testosterone levels and semen parameters in male boron workers under extreme exposure conditions

DUYDU Y., Basaran N., Aydin S., ÜSTÜNDAĞ A., Yalcin C. O., ANLAR H. G., ...More

ARCHIVES OF TOXICOLOGY, vol.92, no.10, pp.3051-3059, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 92 Issue: 10
  • Publication Date: 2018
  • Doi Number: 10.1007/s00204-018-2296-7
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3051-3059
  • Keywords: Boron exposure, Boric acid, Reproductive toxicity, FSH, LH, Testosterone, Semen parameters, REPRODUCTIVE TOXICITY, BANDIRMA
  • Hacettepe University Affiliated: Yes


Boric acid and sodium borates are currently classified in the EU-CLP regulation as "toxic to reproduction" under "Category 1B", with hazard statement of H360FD. However, so far field studies on male reproduction in China and in Turkey could not confirm such boron-associated toxic effects. As validation by another independent study is still required, the present study has investigated possible boron-associated effects on male reproduction in workers (n = 212) under different boron exposure conditions. The mean daily boron exposure (DBE) and blood boron concentration of workers in the extreme exposure group (n = 98) were 47.17 +/- 17.47 (7.95-106.8) mg B/day and 570.6 +/- 160.1 (402.6-1100) ng B/g blood, respectively. Nevertheless, boron-associated adverse effects on semen parameters, as well as on FSH, LH and total testosterone levels were not seen, even within the extreme exposure group. With this study, a total body of evidence has accumulated that allows to conclude that male reproductive effects are not relevant to humans, under any feasible and realistic conditions of exposure to inorganic boron compounds.