Intravenous immunoglobulin in the treatment of severe methotrexate-induced acral erythema

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Atıf İçin Kopyala

Tezer H., Kuskonmaz B. B., KARA A., Devrim I., Tuncer M., CENGİZ A. B., ...Daha Fazla

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, cilt.30, sa.5, ss.391-393, 2008 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 30 Sayı: 5
• Basım Tarihi: 2008
• Doi Numarası: 10.1097/mph.0b013e318168e77c
• Dergi Adı: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.391-393
• Hacettepe Üniversitesi Adresli: Evet

Özet

Chemotherapy-induced acral erythema is an uncommon and dramatic reaction to high-close chemotherapy. It is characterized by painful erythema of both palms and soles with symmetrically well-defined borders, which may progress to bullae formation and desquamation. The bullous variant of this reaction has been reported with methotrexate and more frequently cytosine arabinoside. Rapid differential diagnosis and discrimination from more serious conditions such as graft versus host disease or toxic epidermal necrolysis is essential. In this case report, we present a 13-year-old boy who developed severe and prolonged chemotherapy-induced acral erythema after high-dose methotrexate treatment and successfully responded to intravenous immunoglobulin.