A New Diagnostic and Prognostic Marker in Endometrial Cancer: Neopterin

Bostanci E. I., Dikmen A. U., GİRGİN G., GUNGOR T., Baydar T., DANISMAN A. N.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, cilt.27, sa.4, ss.754-758, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1097/igc.0000000000000952
  • Dergi Adı: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.754-758
  • Anahtar Kelimeler: Endometrial cancer, Neopterin, New marker, IMMUNE-SYSTEM ACTIVATION, PREOPERATIVE CA 125, URINARY NEOPTERIN, OVARIAN-CANCER, FOLLOW-UP, CARCINOMA, INDICATOR, SERUM, LEVEL
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objective In this study, we investigated the correlation between serum and urinary neopterin levels as well as the stage of the disease in women with endometrial cancer. Increased neopterin concentrations are reported in patients with activation of macrophages by interferon-, which includes the following: viral infections, autoimmune disorders, allograft rejection, and various malignant tumors. In patients with several types of cancer, high-neopterin concentrations in body fluids like serum/plasma, urine, ascites, and cerebrospinal fluid indicate the course of the disease, and it is associated with poor prognosis. In the light of foregoing, we aimed to investigate the role of neopterin as a prognostic biomarker in endometrial cancer.