JOURNAL OF CRITICAL & INTENSIVE CARE, vol.13, no.2, pp.73-78, 2022 (ESCI)
Introduction: Septic shock is a serious circulatory disorder with an unacceptable mortality. The detrimental effects of endotoxin such as hypotension and unresponsiveness to both vasodilators and vasoconstrictors were explained by the production of nitric oxide (NO) in copious amounts. Thus it appears feasible to inhibit excessive NO production by using inducible nitric oxide synthase (iNOS) inhibitors in the treatment of septic shock. Therefore, we assessed our hypothesis in a caecal ligation and puncture (CLP) mice model of septic shock in which the overall survival was monitored.