A Patient with Anti-LGI1 Related Autoimmune Limbic Encephalitis who had Frequent and Drug Resistant Seizures


EPILEPSI, vol.22, pp.67-71, 2016 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 22
  • Publication Date: 2016
  • Doi Number: 10.5505/epilepsi.2015.76598
  • Journal Name: EPILEPSI
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.67-71
  • Hacettepe University Affiliated: Yes


Anti-LGI1 auto-antibody related limbic encephalitis is characterized by memory deficits, various neuro-psychiatric symptoms, behavioral disorders and temporal lobe seizures that point to involvement of the limbic system. Neuro-imaging studies reveal abnormal signal intensity in the mesial temporal structures and/or basal ganglia. Seizures are frequently resistant to antiepileptic medications. However they can be dramatically controlled by immunological treatment modalities. A 29-year-old male patient was admitted to our medical center due to long lasting frequent seizures that could not be controlled with four different antiepileptic drugs. However soon after the diagnosis of anti-LGI1 related autoimmune limbic encephalitis, he received IV pulse steroid treatment that lead to complete and rapid cessation of his seizures. Based on this case report, the presenting features, diagnosis and treatment of anti-LGI1 related autoimmune limbic encephalitis are once more stressed.