Central precocious puberty in a girl with Williams syndrome: the result of treatment with GnRH analogue

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Utine G., Alikasifoglu A., Alikasifoglu M., Tuncbilek E.

EUROPEAN JOURNAL OF MEDICAL GENETICS, vol.49, no.1, pp.79-82, 2006 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 49 Issue: 1
• Publication Date: 2006
• Doi Number: 10.1016/j.ejmg.2005.04.020
• Journal Name: EUROPEAN JOURNAL OF MEDICAL GENETICS
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.79-82
• Hacettepe University Affiliated: Yes

Abstract

Williams syndrome (WS) is a well-known microdeletion syndrome characterized by specific facial features, retardation in growth and development, typical personality and cardiac defects. Poor growth potential is further affected by central precocious puberty (CPP) which is frequent in these patients. A WS patient with CPP is presented, whose pubertal development and bone age progression were arrested by administration of GnRH analogues. The case is reported to discuss the role of GnRH analogues for management of CPP in patients with WS. (c) 2005 Elsevier SAS. All rights reserved.