Papillary carcinoma with diffuse papillomatosis of gallbladder and cystic duct

KÖSEMEHMETOĞLU K., AKPINAR E., SÖKMENSÜER C., HAMALOĞLU E.

ANNALS OF DIAGNOSTIC PATHOLOGY, cilt.15, sa.2, ss.140-144, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.anndiagpath.2010.02.004
  • Dergi Adı: ANNALS OF DIAGNOSTIC PATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.140-144
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Biliary papillomatosis and papillary carcinoma are rare tumors of biliary tract; and because of their morphologic similarities, papillomatosis-papillary carcinoma sequel has been proposed. We report an unusual case of polypoid minimally invasive papillary carcinoma located at the junction between cystic and common bile ducts, complicated with biliary papillomatosis of gallbladder and cystic duct, showing focal areas of malignant change. Intrahepatic ducts, hepatic ducts, and distal common bile duct were spared. Both papillomatosis and papillary carcinoma showed areas of high p53 and p21 expression with high proliferative index. Patient is still alive for 4 years without evidence of disease after modified Whipple operation. Possible pathogenetic mechanisms are further discussed. (C) 2011 Elsevier Inc. All rights reserved.