Antivascular therapy for orthotopic human ovarian carcinoma through blockade of the vascular endothelial growth factor and epidermal growth factor receptors

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Thaker P., Yazici S., Nilsson M., Yokoi K., Tsan R., He J., ...More

CLINICAL CANCER RESEARCH, vol.11, no.13, pp.4923-4933, 2005 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 11 Issue: 13
• Publication Date: 2005
• Doi Number: 10.1158/1078-0432.ccr-04-2060
• Journal Name: CLINICAL CANCER RESEARCH
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.4923-4933
• Hacettepe University Affiliated: Yes

Abstract

Purpose: We determined whether the administration of the tyrosine kinase inhibitor, AEE788, which targets the epidermal growth factor receptor and the vascular endothelial growth factor receptor, alone or in combination with paclitaxel, can inhibit progressive growth of human ovarian carcinoma in the peritoneal cavity of female nude mice.