Antivascular therapy for orthotopic human ovarian carcinoma through blockade of the vascular endothelial growth factor and epidermal growth factor receptors

Thaker P., Yazici S., Nilsson M., Yokoi K., Tsan R., He J., ...Daha Fazla

CLINICAL CANCER RESEARCH, cilt.11, sa.13, ss.4923-4933, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 13
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1158/1078-0432.ccr-04-2060
  • Dergi Adı: CLINICAL CANCER RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.4923-4933
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Purpose: We determined whether the administration of the tyrosine kinase inhibitor, AEE788, which targets the epidermal growth factor receptor and the vascular endothelial growth factor receptor, alone or in combination with paclitaxel, can inhibit progressive growth of human ovarian carcinoma in the peritoneal cavity of female nude mice.