CHARACTERIZATION, CELL PROLIFERATION AND CYTOTOXICITY EVALUATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR LOADED POLY (LACTIC-CO-GLYCOLIC ACID) MICROSPHERES

KERİMOĞLU O., ALARÇİN E., Turkoglu M., Dortunc B., Karagoz H., Ulkur E., ...More

NOBEL MEDICUS, vol.8, no.1, pp.77-82, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 1
  • Publication Date: 2012
  • Journal Name: NOBEL MEDICUS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.77-82
  • Hacettepe University Affiliated: Yes

Abstract

Objective: The aim of this study was to encapsulate vascular endothelial growth factor (VEGF) in poly(lactic-co-glycolic acid) (PLGA) microspheres using a water-in-oil-in-water emulsification method. Particle size distribution and surface morphology of PLGA microspheres and VEGF loaded PLGA microspheres were investigated. The effect of VEGF in free form and VEGF loaded in PLGA microspheres were also evaluated in the cell culture for cell proliferation and cytotoxicity.