CHARACTERIZATION, CELL PROLIFERATION AND CYTOTOXICITY EVALUATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR LOADED POLY (LACTIC-CO-GLYCOLIC ACID) MICROSPHERES

KERİMOĞLU O., ALARÇİN E., Turkoglu M., Dortunc B., Karagoz H., Ulkur E., ...Daha Fazla

NOBEL MEDICUS, cilt.8, sa.1, ss.77-82, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 1
  • Basım Tarihi: 2012
  • Dergi Adı: NOBEL MEDICUS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.77-82
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objective: The aim of this study was to encapsulate vascular endothelial growth factor (VEGF) in poly(lactic-co-glycolic acid) (PLGA) microspheres using a water-in-oil-in-water emulsification method. Particle size distribution and surface morphology of PLGA microspheres and VEGF loaded PLGA microspheres were investigated. The effect of VEGF in free form and VEGF loaded in PLGA microspheres were also evaluated in the cell culture for cell proliferation and cytotoxicity.