Epidemiology and management of healthcare-associated bloodstream infections in non-neutropenic immunosuppressed patients: a review of the literature


ÇALIK BAŞARAN N., AŞÇIOĞLU HAYRAN S.

THERAPEUTIC ADVANCES IN INFECTIOUS DISEASE, vol.4, no.6, pp.171-191, 2017 (ESCI) identifier

  • Publication Type: Article / Review
  • Volume: 4 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.1177/2049936117733394
  • Journal Name: THERAPEUTIC ADVANCES IN INFECTIOUS DISEASE
  • Journal Indexes: Emerging Sources Citation Index (ESCI), EMBASE, Directory of Open Access Journals
  • Page Numbers: pp.171-191
  • Hacettepe University Affiliated: Yes

Abstract

Advancements in medicine have led to a considerable increase in the proportion of patients living with severe chronic diseases, malignancies, and HIV infections. Most of these conditions are associated with acquired immune-deficient states and treatment-related immunosuppression. Although infections as a result of neutropenia have long been recognized and strategies for management were developed, non-neutropenic immunosuppression has been overlooked. Recently, community-acquired infections in patients with frequent, significant exposure to healthcare settings and procedures have been classified as healthcare-associated infections' since they are more similar to hospital-acquired infections. Most of the non-neutropenic immunosuppressed patients have frequent contact with the healthcare system due to their chronic and severe diseases. In this review, we focus on the healthcare-associated bloodstream infections in the most common non-neutropenic immunosuppressive states and provide an update of the recent evidence for the management of these infections.