DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current beta-Lactam Antibiotic Doses Sufficient for Critically Ill Patients?

Creative Commons License

Roberts J. A., Paul S. K., AKOVA M., Bassetti M., De Waele J. J., Dimopoulos G., ...More

CLINICAL INFECTIOUS DISEASES, vol.58, no.8, pp.1072-1083, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 8
  • Publication Date: 2014
  • Doi Number: 10.1093/cid/ciu027
  • Journal Name: CLINICAL INFECTIOUS DISEASES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1072-1083
  • Hacettepe University Affiliated: Yes

Abstract

Background. Morbidity and mortality for critically ill patients with infections remains a global healthcare problem. We aimed to determine whether beta-lactam antibiotic dosing in critically ill patients achieves concentrations associated with maximal activity and whether antibiotic concentrations affect patient outcome.