DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current beta-Lactam Antibiotic Doses Sufficient for Critically Ill Patients?

Roberts, Jason; Paul, Sanjoy; AKOVA, MURAT; Bassetti, Matteo; De Waele, Jan; Dimopoulos, George; Kaukonen, Kirsi-Maija; Koulenti, Despoina; Martin, Claude; Montravers, Philippe; Rello, Jordi; Rhodes, Andrew; Starr, Therese; Wallis, Steven; Lipman, Jeffrey

doi:10.1093/cid/ciu027

DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current beta-Lactam Antibiotic Doses Sufficient for Critically Ill Patients?

Roberts J. A., Paul S. K., AKOVA M., Bassetti M., De Waele J. J., Dimopoulos G., ...More

CLINICAL INFECTIOUS DISEASES, vol.58, no.8, pp.1072-1083, 2014 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 58 Issue: 8
Publication Date: 2014
Doi Number: 10.1093/cid/ciu027
Journal Name: CLINICAL INFECTIOUS DISEASES
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1072-1083
Open Archive Collection: AVESIS Open Access Collection
Hacettepe University Affiliated: Yes

Abstract

Background. Morbidity and mortality for critically ill patients with infections remains a global healthcare problem. We aimed to determine whether beta-lactam antibiotic dosing in critically ill patients achieves concentrations associated with maximal activity and whether antibiotic concentrations affect patient outcome.