White blood cell count and ratio changes in newborns after granulocyte colony-stimulating factor treatments

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BÜYÜKEREN M., YİĞİT Ş., ÇELİK H. T., YURDAKÖK M.

PAEDIATRICA INDONESIANA, vol.61, no.5, pp.240-246, 2021 (ESCI, Scopus)

  • Publication Type: Article / Article
  • Volume: 61 Issue: 5
  • Publication Date: 2021
  • Doi Number: 10.14238/pi61.5.2021.240-6
  • Journal Name: PAEDIATRICA INDONESIANA
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, Directory of Open Access Journals
  • Page Numbers: pp.240-246
  • Keywords: newborn, granulocyte colony-stimulating factor, neutropenia, immature/total ratio, PRETERM NEWBORNS, NEUTROPENIA, SEPSIS, TRIAL
  • Open Archive Collection: AVESIS Open Access Collection
  • Hacettepe University Affiliated: Yes

Abstract

Background Granulocyte-colony stimulating factor (G-CSF) is frequently used to treat neonatal neutropenia. There is a paucity of data in the literature on when immature to total neutrophil ratio (I/T ratio) can be accurately used as a sepsis marker after G-CSF therapy, as well as when I/T ratio returns to normal values expected in newborns who did not receive G-CSF.