Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

Min, Josine; Hemani, Gibran; Hannon, Eilis; Dekkers, Koen; Castillo-Fernandez, Juan; Luijk, Rene; Carnero-Montoro, Elena; Lawson, Daniel; Burrows, Kimberley; Suderman, Matthew; Bretherick, Andrew; Richardson, Tom; Klughammer, Johanna; Iotchkova, Valentina; Sharp, Gemma; Al Khleifat, Ahmad; Shatunov, Aleksey; Iacoangeli, Alfredo; McArdle, Wendy; Ho, Karen; Kumar, Ashish; Soderhall, Cilia; Soriano-Tarraga, Carolina; Giralt-Steinhauer, Eva; Kazmi, Nabila; Mason, Dan; McRae, Allan; Corcoran, David; Sugden, Karen; Kasela, Silva; Cardona, Alexia; Day, Felix; Cugliari, Giovanni; Viberti, Clara; Guarrera, Simonetta; Lerro, Michael; Gupta, Richa; Bollepalli, Sailalitha; Mandaviya, Pooja; Zeng, Yanni; Clarke, Toni-Kim; Walker, Rosie; Schmoll, Vanessa; Czamara, Darina; Ruiz-Arenas, Carlos; Rezwan, Faisal; Marioni, Riccardo; Lin, Tian; Awaloff, Yvonne; Germain, Marine; Aissi, Dylan; Zwamborn, Ramona; van Eijk, Kristel; Dekker, Annelot; van Dongen, Jenny; Hottenga, Jouke-Jan; Willemsen, Gonneke; Xu, Cheng-Jian; Barturen, Guillermo; Catala-Moll, Francesc; Kerick, Martin; Wang, Carol; Melton, Phillip; Elliott, Hannah; Shin, Jean; Bernard, Manon; Yet, İDİL; Smarts, Melissa; Gorrie-Stone, Tyler; Shaw, Chris; Al Chalabi, Ammar; Ring, Susan; Pershagen, Goran; Melen, Erik; Jimenez-Conde, Jordi; Roquer, Jaume; Lawlor, Deborah; Wright, John; Martin, Nicholas; Montgomery, Grant; Moffitt, Terrie; Poulton, Richie; Esko, Tonu; Milani, Lili; Metspalu, Andres; Perry, John; Ong, Ken; Wareham, Nicholas; Matullo, Giuseppe; Sacerdote, Carlotta; Panico, Salvatore; Caspi, Avshalom; Arseneault, Louise; Gagnon, France; Ollikainen, Miina; Kaprio, Jaakko; Felix, Janine; Rivadeneira, Fernando; Tiemeier, Henning; van IJzendoorn, Marinus; Uitterlinden, Andre; Jaddoe, Vincent; Hale, Chris; McIntosh, Andrew; Evans, Kathryn; Murray, Alison; Raikkonen, Katri; Lahti, Jari; Nohr, Ellen; Sorensen, Thorkild; Hansen, Torben; Morgen, Camilla; Binder, Elisabeth; Lucae, Susanne; Gonzalez, Juan; Bustamante, Mariona; Sunyer, Jordi; Holloway, John; Karmaus, Wilfried; Zhang, Hongmei; Deary, Ian; Wray, Naomi; Starr, John; Beekman, Marian; VanHeemst, Diana; Slagboom, P.; Morange, Pierre-Emmanuel; Tregouet, David-Alexandre; Veldink, Jan; Davies, Gareth; de Geus, Eco; Boomsma, Dorret; Vonk, Judith; Brunekreef, Bert; Koppelman, Gerard; Alarcon-Riquelme, Marta; Huang, Rae-Chi; Pennell, Craig; van Meurs, Joyce; Ikram, M.; Hughes, Alun; Tillin, Therese; Chaturvedi, Nish; Pausova, Zdenka; Paus, Tomas; Spector, Timothy; Kumari, Meena; Schalkwyk, Leonard; Visscher, Peter; Smith, George; Bock, Christoph; Gaunt, Tom; Bell, Jordana; Heijmans, Bastiaan; Mill, Jonathan; Relton, Caroline

doi:10.1038/s41588-021-00923-x

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

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Min J. L., Hemani G., Hannon E., Dekkers K. F., Castillo-Fernandez J., Luijk R., ...More

NATURE GENETICS, vol.53, no.9, pp.1311-1336, 2021 (SCI-Expanded)

Publication Type: Article / Article
Volume: 53 Issue: 9
Publication Date: 2021
Doi Number: 10.1038/s41588-021-00923-x
Journal Name: NATURE GENETICS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database, DIALNET
Page Numbers: pp.1311-1336
Hacettepe University Affiliated: Yes

Abstract

DNA methylation quantitative trait locus (mQTL) analyses on 32,851 participants identify genetic variants associated with DNA methylation at 420,509 sites in blood, resulting in a database of >270,000 independent mQTLs.