Enantioselective addition of diethylzinc to aldehydes catalyzed by beta-amino alcohols derived from (1R,2S)-norephedrine
APPLIED ORGANOMETALLIC CHEMISTRY, vol.24, no.1, pp.33-37, 2010 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 24 Issue: 1
- Publication Date: 2010
- Doi Number: 10.1002/aoc.1583
- Journal Name: APPLIED ORGANOMETALLIC CHEMISTRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.33-37
- Hacettepe University Affiliated: Yes
Abstract
beta-Amino alcohols derived from (1R,2S)-norephedrine were synthesized and used as ligands in the catalytic enantioselective diethylzinc addition to benzaldehydes. N-alkylated (1R,2S)-norephedrine-based derivative 3a gave the highest enantioselectivity. The effects of different parameters on the enantioselectivity of the product were investigated. Copyright (C) 2009 John Wiley & Sons, Ltd.