Enantioselective addition of diethylzinc to aldehydes catalyzed by beta-amino alcohols derived from (1R,2S)-norephedrine


Tasgin D. I., ÜNALEROĞLU C.

APPLIED ORGANOMETALLIC CHEMISTRY, vol.24, no.1, pp.33-37, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 1
  • Publication Date: 2010
  • Doi Number: 10.1002/aoc.1583
  • Journal Name: APPLIED ORGANOMETALLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.33-37
  • Hacettepe University Affiliated: Yes

Abstract

beta-Amino alcohols derived from (1R,2S)-norephedrine were synthesized and used as ligands in the catalytic enantioselective diethylzinc addition to benzaldehydes. N-alkylated (1R,2S)-norephedrine-based derivative 3a gave the highest enantioselectivity. The effects of different parameters on the enantioselectivity of the product were investigated. Copyright (C) 2009 John Wiley & Sons, Ltd.