Enantioselective addition of diethylzinc to aldehydes catalyzed by beta-amino alcohols derived from (1R,2S)-norephedrine

Tasgin D. I., ÜNALEROĞLU C.

APPLIED ORGANOMETALLIC CHEMISTRY, cilt.24, sa.1, ss.33-37, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 1
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1002/aoc.1583
  • Dergi Adı: APPLIED ORGANOMETALLIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.33-37
  • Hacettepe Üniversitesi Adresli: Evet

Özet

beta-Amino alcohols derived from (1R,2S)-norephedrine were synthesized and used as ligands in the catalytic enantioselective diethylzinc addition to benzaldehydes. N-alkylated (1R,2S)-norephedrine-based derivative 3a gave the highest enantioselectivity. The effects of different parameters on the enantioselectivity of the product were investigated. Copyright (C) 2009 John Wiley & Sons, Ltd.