Facile synthesis of heteroaryl substituted gamma-lactams from nitrovinyl arenes


Cinar S., ÜNALEROĞLU C.

TURKISH JOURNAL OF CHEMISTRY, vol.42, no.1, pp.29-35, 2018 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.3906/kim-1705-25
  • Journal Name: TURKISH JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded, Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.29-35

Abstract

Aliphatic nitroalkanes with different functional groups were synthesized from the Michael addition reactions of active methylene compounds 2 and nitrovinyl arenes 1 in high yields. The synthesized Michael adducts were subjected to intramolecular cyclization to give heteroaryl substituted gamma-lactams in good to high yields under mild reaction conditions.