Facile synthesis of heteroaryl substituted gamma-lactams from nitrovinyl arenes

Cinar S., ÜNALEROĞLU C.

TURKISH JOURNAL OF CHEMISTRY, cilt.42, sa.1, ss.29-35, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.3906/kim-1705-25
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.29-35
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Aliphatic nitroalkanes with different functional groups were synthesized from the Michael addition reactions of active methylene compounds 2 and nitrovinyl arenes 1 in high yields. The synthesized Michael adducts were subjected to intramolecular cyclization to give heteroaryl substituted gamma-lactams in good to high yields under mild reaction conditions.