The penetration of ofloxacin into human aqueous humor given by various routes


Hanioglu-Kargi S., Basci N. E. , Soysal H., Bozkurt A., Gursel E., Kayaalp O.

EUROPEAN JOURNAL OF OPHTHALMOLOGY, vol.8, no.1, pp.33-36, 1998 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 1
  • Publication Date: 1998
  • Doi Number: 10.1177/112067219800800108
  • Journal Name: EUROPEAN JOURNAL OF OPHTHALMOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.33-36

Abstract

This study was designed to measure the concentration of ofloxacin in aqueous humor after topical, oral and intravenous administration in 50 patients undergoing cataract extraction. In Group I, ofloxacin 0.3% eyedrops were topically instilled ten times and the aqueous humor concentration was 2.73 +/- 0.88 mu g/ml. In Group 2, ofloxacin 0.3% eyedrops were topically instilled six times and the aqueous humor concentration was 0.84 +/- 0.61 mu g/ml. Aqueous humor concentration 12 hours after 200 mg oral dose in Group 3, was 0.38 +/- 0.12 mu g/ml. In Group 4, patients were given ofloxacin as a single intravenous 200 mg dose and the aqueous humor concentration 2 hours after the end of infusion was 0.45 +/- 0.11 mu g/ml. Concentrations were determined by high performance liquid chromatography (HPLC) with fluorescence detection.