Distribution of RET Mutations and Evaluation of Treatment Approaches in Hereditary Medullary Thyroid Carcinoma in Turkey

Aydogan, Berna; Yuksel, Bagdagul; Tuna, Mazhar; Basaran, Mehtap; Kocaeli, Aysen; Ertorer, Melek; Aydin, Kadriye; GÜLDİKEN, SİBEL; ŞİMŞEK, Yasin; Karaca, Zuleyha; Yilmaz, MERVE; Akturk, Mujde; Anaforoglu, Inan; Kebapci, Nur; Duran, Cevdet; Taslipinar, Abdullah; KULAKSIZOĞLU, MUSTAFA; Gursoy, Alptekin; DAĞDELEN, SELÇUK; Erdogan, Murat

doi:10.4274/jcrpe.2219

Distribution of RET Mutations and Evaluation of Treatment Approaches in Hereditary Medullary Thyroid Carcinoma in Turkey

Aydogan B. I., Yuksel B., Tuna M. M., Basaran M. N., Kocaeli A. A., Ertorer M. E., ...More

JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, vol.8, no.1, pp.13-20, 2016 (SCI-Expanded, Scopus, TRDizin)

Publication Type: Article / Article
Volume: 8 Issue: 1
Publication Date: 2016
Doi Number: 10.4274/jcrpe.2219
Journal Name: JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Page Numbers: pp.13-20
Keywords: Sporadic medullary thyroid carcinoma, hereditary medullary thyroid carcinoma, multiple endocrine neoplasia, RET mutation, ENDOCRINE NEOPLASIA TYPE-2, PROTOONCOGENE MUTATIONS, MEN 2A, PREVALENCE, FAMILIES, CANCER, GUIDELINES, MANAGEMENT, EXPERIENCE, PHENOTYPE
Open Archive Collection: AVESIS Open Access Collection
Hacettepe University Affiliated: Yes

Abstract

Objective: This retrospective multicenter study, centrally conducted and supported by the Society of Endocrinology and Metabolism of Turkey, aimed to evaluate the impact of free RET proto-oncogene testing in medullary thyroid carcinoma (MTC) patients. Surgical timing, adequacy of the treatment, and frequency of prophylactic thyroidectomy (PTx) in mutation carriers were also assessed.