E-Beam Processing of Collagen-Poly(N-vinyl-2-pyrrolidone) Double-Network Superabsorbent Hydrogels: Structural and Rheological Investigations


DEMETER M., CALINA I., VANCEA C., ŞEN M., KAYA M. G. A. , MANAILA E., ...More

MACROMOLECULAR RESEARCH, vol.27, no.3, pp.255-267, 2019 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 3
  • Publication Date: 2019
  • Doi Number: 10.1007/s13233-019-7041-4
  • Journal Name: MACROMOLECULAR RESEARCH
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.255-267
  • Keywords: e-beam, hydrogels, cross-linking, collagen, PVP, POLY(VINYL PYRROLIDONE) PVP, GAMMA-RAY IRRADIATION, INDUCED CROSS-LINKING, MECHANICAL-PROPERTIES, POLYVINYLPYRROLIDONE PVP, COLLAGEN, ACID, PH, BEHAVIOR, GEL

Abstract

Collagen (C)-poly(N-vinyl-2-pyrrolidone) (PVP) double-network superabsorbent hydrogels were synthesized by e-beam (electron beam) radiation processing, both with the addition of water-soluble cross-linking agents (CA), as well as without CA. The aim of the study was to develop a hydrogel for future application as wound dressings via e-beam radiation cross-linking of two biocompatible polymers. The formation of C-PVP hydrogels was confirmed by Fourier transform infrared (FTIR) spectroscopy and their performance was determined from morphological and rheological experiments, such as sol-gel analysis, swelling capacity, storage (G) and viscous (G) moduli, cross-linking density, and pore size. Sol-gel analysis was performed in order to determine the gel properties as function of absorbed dose and it was found that the degradation density (p(0))/cross-linking density (q(0)) ratio indicates a negligible contribution of chain scission processes. The rheological data confirmed that the elastic properties were predominant: G moduli were larger than G moduli, as is specific to elastic solids and indicate the formation of a permanent hydrogel network were cross-links are present. Moreover, the swelling studies indicated that the hydrogels have good stability both in deionized water and phosphate-buffered saline (PBS) solution at 37 degrees C, and superabsorbent properties. The hydrogels network parameters obtained with lower content of CA, could be controlled by changing the absorbed dose.