Secondary metabolites from the roots of <i>Astragalus trojanus</i>

Bedir E., Çalis I., Aquino R., Piacente S., Pizza C.

JOURNAL OF NATURAL PRODUCTS, no.4, pp.563-568, 1999 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 1999
  • Doi Number: 10.1021/np980399t
  • Journal Name: JOURNAL OF NATURAL PRODUCTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Page Numbers: pp.563-568
  • Hacettepe University Affiliated: Yes

Abstract

Six novel cycloartane-type glycosides were isolated from the roots of Astragalus trojanus. Two of these, compounds 1; and 2, have (20R,24S)-epoxy-3 beta,6 alpha,16 beta,25-tetrahydroxycycloartane as the aglycon, while compounds 3-6 possess 3 beta,6 alpha, 16 beta,(24S),25-pentahydroxycycloartane as the aglycon: The saccharide moieties linked to the C-3, C-6, and C-24 or C-25 positions of the aglycons in 1-6 contained either xylopyranose, glucopyranose, rhamnopyranose, or arabinopyranose units. Structure elucidation of compounds 1-6 was accomplished through the extensive use of 1D and 2D NMR techniques. In addition, a new oleanene glycoside (7) and a new tryptophan derivative (8) were also isolated and characterized.