The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma - Correlations with clinical features
CANCER, cilt.100, sa.8, ss.1605-1614, 2004 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 100 Sayı: 8
- Basım Tarihi: 2004
- Doi Numarası: 10.1002/cncr.20137
- Dergi Adı: CANCER
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1605-1614
- Hacettepe Üniversitesi Adresli: Evet
Özet
BACKGROUND. FHIT and WWOX are a tumor suppressor and a candidate suppressor that encompass the FRA3B and FRA16D fragile sites at chromosomes 3p14.2 and 16q23.3-24.1, respectively. Reduced or absent Fhit expression has been reported in two-thirds of invasive breast tumors in association with adverse prognostic factors. Loss of 16q has been reported frequently in low-grade, invasive breast tumors.