The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma - Correlations with clinical features


Guler G. , ÜNER A. , Guler N., Han S., Iliopoulos D., Hauck W., ...More

CANCER, vol.100, no.8, pp.1605-1614, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 100 Issue: 8
  • Publication Date: 2004
  • Doi Number: 10.1002/cncr.20137
  • Title of Journal : CANCER
  • Page Numbers: pp.1605-1614

Abstract

BACKGROUND. FHIT and WWOX are a tumor suppressor and a candidate suppressor that encompass the FRA3B and FRA16D fragile sites at chromosomes 3p14.2 and 16q23.3-24.1, respectively. Reduced or absent Fhit expression has been reported in two-thirds of invasive breast tumors in association with adverse prognostic factors. Loss of 16q has been reported frequently in low-grade, invasive breast tumors.