Characterization and in vivo evaluation of ocular minitablets prepared with different bioadhesive Carbopol-starch components

Weyenberg, W; Bozdag, SİBEL; Foreman, P; Remon, JP; Ludwig, A

doi:10.1016/j.ejpb.2005.08.003

Characterization and in vivo evaluation of ocular minitablets prepared with different bioadhesive Carbopol-starch components

Weyenberg W., Bozdag S., Foreman P., Remon J., Ludwig A.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, cilt.62, sa.2, ss.202-209, 2006 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 62 Sayı: 2
Basım Tarihi: 2006
Doi Numarası: 10.1016/j.ejpb.2005.08.003
Dergi Adı: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.202-209
Hacettepe Üniversitesi Adresli: Evet

Özet

The purpose of this study was to evaluate different bioadhesive ocular formulations based on drum dried waxy maize (R) starch (DDWM), Amioca (R) starch and Carbopol (R) 974P. The concentrations of Carbopol (R) 974P in the mixtures varied between 5 and 25% (w/w). The rheological properties of the non-sterilized and gamma-irradiated physical blends of Carbopolo 974P with either DDWM or Amioca (R) were compared to those of the corresponding co-spray dried Amioca (R) starch/Carbopol (R) powders. Higher viscosity or consistency values were measured for sterilized co-spray dried powder mixtures containing an amount of Carbopol (R) 974P equal or above 15% (w/w) compared to the physical blends.