Identification of point mutations and large rearrangements in the BRCA1 gene in 667 Turkish unselected ovarian cancer patients

Aktas, D.; GÜLTEKİN, MURAT; Kabacam, S.; Alikasifoglu, M.; Turan, A.; Tulunay, G.; Kose, M.; Ortac, F.; Yuce, KUNTER; Tuncbilek, ERGÜL; Ayhan, ALİ

doi:10.1016/j.ygyno.2010.05.018

Identification of point mutations and large rearrangements in the BRCA1 gene in 667 Turkish unselected ovarian cancer patients

Aktas D., GÜLTEKİN M., Kabacam S., Alikasifoglu M., Turan A. T., Tulunay G., ...Daha Fazla

GYNECOLOGIC ONCOLOGY, cilt.119, sa.1, ss.131-135, 2010 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 119 Sayı: 1
Basım Tarihi: 2010
Doi Numarası: 10.1016/j.ygyno.2010.05.018
Dergi Adı: GYNECOLOGIC ONCOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.131-135
Hacettepe Üniversitesi Adresli: Evet

Özet

Objective. The aim of this study was to evaluate the prevalence and spectrum of a known founder mutation, 5382insC and large genomic rearrangements (LGRs) in BRCA1 in ovarian cancer patients in Turkey. The additional aim was to determine the genetic testing strategy in Turkish breast/ovarian cancer family.