Perfluorooctanoic acid affects mouse brain and liver tissue through oxidative stress.


Endirlik B. Ü. , Eken A., Canpınar H., Öztürk F., Gürbay A.

Arhiv za higijenu rada i toksikologiju, vol.73, no.2, pp.148-157, 2022 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 73 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.2478/aiht-2022-73-3629
  • Journal Name: Arhiv za higijenu rada i toksikologiju
  • Journal Indexes: Science Citation Index Expanded
  • Page Numbers: pp.148-157
  • Keywords: body weight, CAT, CoQ(10), GPx, GSH, hepatotoxicity, in vivo, neurotoxicity, oxidative damage, PFOA, relative organ weight, SOD, taurine, AMMONIUM PERFLUOROOCTANOATE, POLYFLUORINATED COMPOUNDS, PEROXISOME PROLIFERATOR, EXPOSURE, PFOA, GLUTATHIONE, COENZYME-Q10, INDUCTION, SULFONATE, APOPTOSIS

Abstract

The aim of this study was to investigate oxidative stress induced by perfluorooctanoic acid (PFOA) in the brain and liver tissues of Balb/c mice as well as protective effects of taurine and coenzyme Q(10) (CoQ(10)) in both organs. For this purpose, animals were treated with PFOA (15 and 30 mg/kg) orally and their lipid peroxidation, total glutathione levels (GSH), and antioxidant enzyme activities measured and both tissues analysed for histopathological changes. Our results showed a dose-dependent decrease in body weight and increase in relative brain and liver weights, PFOA-induced lipid peroxidation and reduced glutathione peroxidase (GPx) activity in the brain tissue, and changes in GSH levels, GPx, superoxide dismutase (Cu-Zn SOD), and catalase (CAT) activities in the liver tissue. Pre-treatment with taurine or CoQ(10) provided protection against PFOA-induced Cu-Zn SOD reduction in the liver tissue. Our findings evidence the depleting effect of PFOA on antioxidative systems and confirm that PFOA exerts its (neuro)toxicity through oxidative stress, but further research is needed to identify the exact toxicity mechanisms, especially in the brain.