The effects of transient systemic hypotension on renal oxidative status, morphology and plasma nitric oxide levels in pregnant rats


BAYRAK S. , PEHLİVANOĞLU B. , BALKANCI Z. D. , OZYUREK H., AKSOY Y. , ATİLLA P. , ...More

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, vol.22, no.6, pp.528-536, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 6
  • Publication Date: 2009
  • Doi Number: 10.1080/14767050902822229
  • Title of Journal : JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
  • Page Numbers: pp.528-536

Abstract

Objective. Transient hypotension attacks, frequently experienced during pregnancy, have detrimental effects on maternal and fetal physiology. Despite the strong autoregulatory mechanisms, kidneys are remarkably sensitive to hypoperfusion. Transient hypotension together with high metabolic demand and increased oxygen requirement during pregnancy may disturb the oxidant status and natural course of nitric oxide (NO) metabolism. Therefore, we investigated in this study the effects of systemic hypotension during pregnancy on kidney oxidant status and morphology and plasma NO levels in an experimental hypotension model in rats.