The effects of transient systemic hypotension on renal oxidative status, morphology and plasma nitric oxide levels in pregnant rats

BAYRAK, SİBEL; PEHLİVANOĞLU, BİLGE; BALKANCI, ZEYNEP; OZYUREK, Hamit; AKSOY, YASEMİN; ATİLLA, PERGİN; Cakar, AYŞE

doi:10.1080/14767050902822229

The effects of transient systemic hypotension on renal oxidative status, morphology and plasma nitric oxide levels in pregnant rats

Atıf İçin Kopyala

BAYRAK S., PEHLİVANOĞLU B., BALKANCI Z. D., OZYUREK H., AKSOY Y., ATİLLA P., ...Daha Fazla

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, cilt.22, sa.6, ss.528-536, 2009 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 22 Sayı: 6
Basım Tarihi: 2009
Doi Numarası: 10.1080/14767050902822229
Dergi Adı: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.528-536
Hacettepe Üniversitesi Adresli: Evet

Özet

Objective. Transient hypotension attacks, frequently experienced during pregnancy, have detrimental effects on maternal and fetal physiology. Despite the strong autoregulatory mechanisms, kidneys are remarkably sensitive to hypoperfusion. Transient hypotension together with high metabolic demand and increased oxygen requirement during pregnancy may disturb the oxidant status and natural course of nitric oxide (NO) metabolism. Therefore, we investigated in this study the effects of systemic hypotension during pregnancy on kidney oxidant status and morphology and plasma NO levels in an experimental hypotension model in rats.