Frequency and enzyme activity of the butyrylcholinesterase K-variant in a Turkish population

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Babaoglu M., Ocal T., Bayar B., Kayaalp S., Bozkurt A.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, vol.59, no.12, pp.875-877, 2004 (SCI-Expanded, Scopus)

• Publication Type: Article / Article
• Volume: 59 Issue: 12
• Publication Date: 2004
• Doi Number: 10.1007/s00228-003-0716-x
• Journal Name: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.875-877
• Hacettepe University Affiliated: Yes

Abstract

Objective. Among variants of the butyrylcholinesterase gene (BChE), the K-variant causing Ala539Thr substitution is the most common one associated with about one-third reduction in the enzyme activity. This study aimed to detect the frequency of the K-variant allele in a Turkish population sample and also to evaluate how the plasma BChE activity was influenced by this variant.