Frequency and enzyme activity of the butyrylcholinesterase K-variant in a Turkish population

Babaoglu M., Ocal T., Bayar B., Kayaalp S., Bozkurt A.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, cilt.59, sa.12, ss.875-877, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 12
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1007/s00228-003-0716-x
  • Dergi Adı: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.875-877
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objective. Among variants of the butyrylcholinesterase gene (BChE), the K-variant causing Ala539Thr substitution is the most common one associated with about one-third reduction in the enzyme activity. This study aimed to detect the frequency of the K-variant allele in a Turkish population sample and also to evaluate how the plasma BChE activity was influenced by this variant.