The aim of this study was to determine the knowledge, opinions and behaviors of the adults, regarding Crimean-Congo Hemorrhagic Fever (CCHF). This descriptive study data was collected from 405 adults who attended two health centers in Ankara city. The mean age of the adults was 38.2 +/- 14.5 years, 73.8% were female, and 63.0% had an educational level of secondary school or below. Of them, 91.6% were not involved with activities, which might have created risk in terms of CCHF. When the name of the disease or the tick was mentioned, 86.7% declared that they heard CCHF. The males (P<0.001). people with educational level of high school or more (P<0.001) and those who are currently working (P=0.004) heard CCHF more compared to others. Of the study population, 89.8% declared that disease was transmitted by ticks and caused fever (83.8%) and 65.0% knew there were ways of prevention from the disease. Mean knowledge score of CCHF was found to be 17.5 +/- 8.3 (min-max=0-30, median=20). Being younger than SO years of age (P=0.003), being male (P=0.003), having an educational level of high school or higher (P<0.001), and working (P<0.001) increased the CCHF knowledge score. The study population did not have enough knowledge regarding CCHF. In order to increase the knowledge level, there should be cooperation among health authorities, health workers, veterinary public health service providers, educators, local authorities and the media.