SYNTHESIS AND BIOLOGICAL EVALUATIONS OF SOME 2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE DERIVATIVES

ERTAN M., BALKAN A., SARAC S., UMA S., RUBSEMAN K., RENAUD J.

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, sa.7, ss.725-727, 1991 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 1991
  • Dergi Adı: ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, International Pharmaceutical Abstracts
  • Sayfa Sayıları: ss.725-727
  • Hacettepe Üniversitesi Adresli: Hayır

Özet

Several 1,2,3,4-tetrahydro-6-methyl-4-(substituted phenyl)-2-thioxo-5-pyrimidinecarboxylic acid methyl esters were synthesized by condensing thiourea with methyl aceto-acetate and substituted benzaldehydes according to Biginelli reaction. The structures of the compounds were confirmed by spectral and elemental analysis and their calcium antagonistic activities were investigated. Furthermore, the compounds synthesized in previous and present studies were evaluated for their antiaggregating activities.