SYNTHESIS AND BIOLOGICAL EVALUATIONS OF SOME 2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE DERIVATIVES


ERTAN M., BALKAN A., SARAC S., UMA S., RUBSEMAN K., RENAUD J.

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, no.7, pp.725-727, 1991 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 1991
  • Journal Name: ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH
  • Journal Indexes: Science Citation Index Expanded, Scopus, International Pharmaceutical Abstracts
  • Page Numbers: pp.725-727

Abstract

Several 1,2,3,4-tetrahydro-6-methyl-4-(substituted phenyl)-2-thioxo-5-pyrimidinecarboxylic acid methyl esters were synthesized by condensing thiourea with methyl aceto-acetate and substituted benzaldehydes according to Biginelli reaction. The structures of the compounds were confirmed by spectral and elemental analysis and their calcium antagonistic activities were investigated. Furthermore, the compounds synthesized in previous and present studies were evaluated for their antiaggregating activities.