Effects of oral cyclophosphamide and prednisolone therapy on the endothelial functions and clinical findings in patients with early diffuse systemic sclerosis

Apras S., Ertenli I., Ozbalkan Z., Kiraz S., Ozturk M., Haznedaroglu I. , ...Daha Fazla

ARTHRITIS AND RHEUMATISM, cilt.48, sa.8, ss.2256-2261, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Konu: 8
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1002/art.11081
  • Sayfa Sayıları: ss.2256-2261


Objective. The endothelial damage of microvascular structures in systemic sclerosis (SSc; scleroderma) is associated with increased levels of endothelial adhesion molecules and endothelium-associated cytokines, including E-selectin and thrombomodulin. Although there is still no ideal specific pharmacologic therapy for SSc, cyclophosphamide has resulted in clinical improvement in patients with SSc-related active alveolitis. This study was designed to assess the expression of E-selectin and thrombomodulin in patients with early diffuse SSc, and to investigate the effects of oral cyclophosphamide combined with prednisolone therapy on the levels of these endothelium-associated cytokines and on the patients' clinical outcomes.