Effects of oral cyclophosphamide and prednisolone therapy on the endothelial functions and clinical findings in patients with early diffuse systemic sclerosis

Apras, S; Ertenli, I; Ozbalkan, Z; Kiraz, S; Ozturk, MA; Haznedaroglu, İBRAHİM; Cobankara, V; Pay, S; Calguneri, M

doi:10.1002/art.11081

Effects of oral cyclophosphamide and prednisolone therapy on the endothelial functions and clinical findings in patients with early diffuse systemic sclerosis

Apras S., Ertenli I., Ozbalkan Z., Kiraz S., Ozturk M., Haznedaroglu I., ...Daha Fazla

ARTHRITIS AND RHEUMATISM, cilt.48, sa.8, ss.2256-2261, 2003 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 48 Sayı: 8
Basım Tarihi: 2003
Doi Numarası: 10.1002/art.11081
Dergi Adı: ARTHRITIS AND RHEUMATISM
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.2256-2261
Hacettepe Üniversitesi Adresli: Evet

Özet

Objective. The endothelial damage of microvascular structures in systemic sclerosis (SSc; scleroderma) is associated with increased levels of endothelial adhesion molecules and endothelium-associated cytokines, including E-selectin and thrombomodulin. Although there is still no ideal specific pharmacologic therapy for SSc, cyclophosphamide has resulted in clinical improvement in patients with SSc-related active alveolitis. This study was designed to assess the expression of E-selectin and thrombomodulin in patients with early diffuse SSc, and to investigate the effects of oral cyclophosphamide combined with prednisolone therapy on the levels of these endothelium-associated cytokines and on the patients' clinical outcomes.