Reduced irisin levels in patients with acromegaly

Şendur S. N., Baykal G., Fırlatan B., Aydin B., Lay İ., Dağdelen S., ...More

HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION, vol.43, no.3, pp.251-261, 2022 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.1515/hmbci-2022-0009
  • Journal Name: HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.251-261
  • Keywords: acromegaly, FNDC5 polymorphism, irisin, somatostatin receptor ligand, ADIPOSE-TISSUE, DIABETES-MELLITUS, FNDC5, METABOLISM, GLUCOSE, GENE, CONSENSUS, CRITERIA, SERUM, CURE
  • Hacettepe University Affiliated: Yes

Abstract

Objectives: Several metabolic disturbances are seen in acromegaly however, data regarding the contribution of irisin to these disturbances is currently insufficient. In a cohort of patients with acromegaly, we measured serum irisin levels in active and controlled cases and determined independent factors that effect serum irisin including fibronectin type III domain-containing protein 5 (FNDC5) genotyping.