Lycopene sensitizes the cervical cancer cells to cisplatin via targeting nuclear factor- kappa B (NF-κB) pathway


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Aktepe O. H. , Şahin T. K. , Güner G., Arik Z., Yalçin Ş.

Turkish journal of medical sciences, vol.51, pp.368-374, 2021 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51
  • Publication Date: 2021
  • Doi Number: 10.3906/sag-2005-413
  • Journal Name: Turkish journal of medical sciences
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.368-374
  • Keywords: Lycopene, cervix cancer, cancer treatment, chemotherapy, BREAST-CANCER, NRF2, INHIBITION, RESISTANCE, APOPTOSIS, EXPRESSION, SURVIVAL

Abstract

Background/aim: Lycopene is associated with anticancer effects in various tumor types. However, the exact underlying mechanisms of action of lycopene in human cervical cancer remain to be determined. This study aimed to determine anticancer efficacy and mechanism of lycopene in human cervical carcinoma (HeLa) cells.