Bocavirus Infection as a Potential Trigger for Hepatic Injury in Children

Seyrek B. E., AYKAÇ K., Temizel I. S., Cengiz A. B., ÖZSÜREKCİ Y.

JOURNAL OF VIRAL HEPATITIS, no.3, 2025 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2025
  • Doi Number: 10.1111/jvh.70013
  • Journal Name: JOURNAL OF VIRAL HEPATITIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, MEDLINE, Veterinary Science Database
  • Hacettepe University Affiliated: Yes

Abstract

Human Bocavirus (HBoV) is an emerging pathogen linked to respiratory and gastrointestinal infections in children. While its role in respiratory diseases is established, its association with liver dysfunction remains unclear. This study presents six paediatric cases of elevated liver enzymes or acute liver failure during HBoV infection, including severe outcomes such as liver transplantation and one fatality. Frequent co-infections with other pathogens were noted, complicating the clinical course. Although direct evidence of HBoV's role in liver involvement is lacking, its potential contribution warrants further investigation to guide clinical management.