Synthesis of novel norephedrine-based chiral ligands with multiple stereogenic centers and their application in enantioselective addition of diethylzinc to aldehyde and chalcone

Unaleroglu, CANAN; Aydin, Alime; Demir, Ayhan

doi:10.1016/j.tetasy.2006.02.005

Synthesis of novel norephedrine-based chiral ligands with multiple stereogenic centers and their application in enantioselective addition of diethylzinc to aldehyde and chalcone

Atıf İçin Kopyala

Unaleroglu C., Aydin A. E., Demir A. S.

TETRAHEDRON-ASYMMETRY, cilt.17, sa.5, ss.742-749, 2006 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 17 Sayı: 5
Basım Tarihi: 2006
Doi Numarası: 10.1016/j.tetasy.2006.02.005
Dergi Adı: TETRAHEDRON-ASYMMETRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.742-749
Hacettepe Üniversitesi Adresli: Evet

Özet

Novel norephedrine-based chiral ligands with multiple stereogenic centers were conveniently prepared from norephedrine and N-substituted pyrrole. These novel chiral ligands were used to catalyze the enantioselective addition of diethylzinc to aldehydes and to chalcone in high yields and with good to high enantioselectivities. The absolute configuration of products was found to be affected by the stereogenic centers on the norephedrine part of the novel chiral ligands. (c) 2006 Elsevier Ltd. All rights reserved.