Relationship of PON2 gene Ser311Cys polymorphism and serum paraoxonase activity with coronary artery disease in Turkish population

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Bayrak T., Bayrak A., VOLKAN SALANCI B., Deniz A., TOKGÖZOĞLU S. L., YAVUZ B., ...More

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.37, no.2, pp.150-155, 2012 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 37 Issue: 2
• Publication Date: 2012
• Doi Number: 10.5505/tjb.2012.58066
• Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.150-155
• Hacettepe University Affiliated: Yes

Abstract

Objective: Paraoxonase-2 (PON2) is a cellular enzyme that has antioxidant properties similar to PON1, an HDL-associated serum enzyme playing an important role in the prevention of atherosclerosis. 1. The aim of this study is to investigate whether serum paraoxonase activity and PON2 Ser311Cys polymorphism are related to coronary artery disease and the extent of atherosclerosis.