Increased ACE in extrahepatic cholangiocarcinoma as a clue for activated RAS in biliary neoplasms

Beyazit, Yavuz; Purnak, Tugrul; Suvak, Burak; Kurt, Mevlut; Sayilir, Abdurrahim; Turhan, Turan; Tas, Adnan; Torun, Serkan; Celik, Tugrul; Ibis, Mehmet; HAZNEDAROĞLU, İBRAHİM

doi:10.1016/j.clinre.2011.06.008

Increased ACE in extrahepatic cholangiocarcinoma as a clue for activated RAS in biliary neoplasms

Beyazit Y., Purnak T., Suvak B., Kurt M., Sayilir A., Turhan T., ...Daha Fazla

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, cilt.35, sa.10, ss.644-649, 2011 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 35 Sayı: 10
Basım Tarihi: 2011
Doi Numarası: 10.1016/j.clinre.2011.06.008
Dergi Adı: CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.644-649
Hacettepe Üniversitesi Adresli: Evet

Özet

Aim: Cholangiocarcinoma (CCA) is a primary neoplastic tumor of the epithelial lining of the biliary tree which carries a poor prognosis despite combined therapeutic strategies. Although the exact etiology remains obscure, it has been suggested that locally produced Angiotensin II (Ang II) in intrahepatic CCA tissues plays a key role in the proliferation and activation of CCA. In the present study, we aimed to analyze the relationship between the levels of circulating angiotensin converting enzyme (ACE), an important molecule of the renin-angiotensin system (RAS), and biliary disorders.