Increased ACE in extrahepatic cholangiocarcinoma as a clue for activated RAS in biliary neoplasms

Beyazit Y., Purnak T., Suvak B., Kurt M., Sayilir A., Turhan T., ...More

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, vol.35, no.10, pp.644-649, 2011 (SCI-Expanded) identifier identifier identifier


Aim: Cholangiocarcinoma (CCA) is a primary neoplastic tumor of the epithelial lining of the biliary tree which carries a poor prognosis despite combined therapeutic strategies. Although the exact etiology remains obscure, it has been suggested that locally produced Angiotensin II (Ang II) in intrahepatic CCA tissues plays a key role in the proliferation and activation of CCA. In the present study, we aimed to analyze the relationship between the levels of circulating angiotensin converting enzyme (ACE), an important molecule of the renin-angiotensin system (RAS), and biliary disorders.