EVALUATION OF GENOTOXIC EFFECTS OF TWO POLYCYCLIC AROMATIC HYDROCARBONS WITH ALLIUM TEST


KORKMAZ F., GÖMÜRGEN A. N. , Mercangoz A.

FRESENIUS ENVIRONMENTAL BULLETIN, vol.18, no.12, pp.2306-2311, 2009 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 12
  • Publication Date: 2009
  • Journal Name: FRESENIUS ENVIRONMENTAL BULLETIN
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.2306-2311

Abstract

In the present study, the genotoxicity risks of two 9-aryl substituted phenanthrene derivates synthesized as drug precursors were tested with Allium test. 9-(5-nitro-1H-benzimidazol-2-yl) phenanthren decreased the mitotic index (MI), and increased chromosome aberrations, among them C-metaphase, sticky metaphase, disturbed metaphase, lost chromosome at metaphase, polyploidy, disturbed anaphase, anaphase bridge, anaphase bridge with lost chromosome, chromosome break at anaphase and micronuclei formation. 9-(5-nitro-1H-benzimidazol-2-yl) phenanthrene has shown genotoxic effects, while 9-(phenanthro [9,10-d] imidazol-2-yl) phenanthrene had not any genotoxic effect.