Selective estrogen receptor modulation prevents scoliotic curve progression: radiologic and histomorphometric study on a bipedal C57Bl6 mice model

Demirkiran, HALİL; Dede, Ozgur; Yalcin, Nadir; Akel, Ibrahim; Marcucio, Ralph; Acaroglu, Emre

doi:10.1007/s00586-013-3072-2

Selective estrogen receptor modulation prevents scoliotic curve progression: radiologic and histomorphometric study on a bipedal C57Bl6 mice model

Demirkiran G., Dede O., Yalcin N., Akel I., Marcucio R., Acaroglu E.

EUROPEAN SPINE JOURNAL, cilt.23, sa.2, ss.455-462, 2014 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 23 Sayı: 2
Basım Tarihi: 2014
Doi Numarası: 10.1007/s00586-013-3072-2
Dergi Adı: EUROPEAN SPINE JOURNAL
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.455-462
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Hacettepe Üniversitesi Adresli: Evet

Özet

Previous work has suggested that progression of experimental scoliotic curves in pinealectomized chicken and bipedal C57BL6 mice models may be prevented and reversed with Tamoxifen treatment. Raloxifene is another Selective Estrogen Receptor Modulator (SERM) with estrogen agonist effects on bone and increases bone density but with fewer side effects on humans. To investigate whether scoliosis progression in bipedal C57Bl6 mice model could be prevented with SERM treatment and the mechanisms associated with this effect.