Analgesic activity of acylated 2-benzoxazolinone derivatives

GÖKHAN KELEKÇİ N., ERDOĞAN H., KANDİLCİ N. T., Demirdamar R.

FARMACO, cilt.54, ss.112-115, 1999 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1016/s0014-827x(98)00111-6
  • Dergi Adı: FARMACO
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.112-115
  • Anahtar Kelimeler: 2-benzoxazolinone, acylation, analgesic activity, 6-METHOXYBENZOXAZOLINONE, BENZOXAZOLINONE, MELATONIN
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Ten new benzoxazolinone derivatives having a disubstituted benzoyl group at the six position of the ring were synthesized by reacting 2-benzoxazolinone with aromatic carboxylic acids in the presence of polyphosphoric acid. The structure of the compounds were elucidated by IR,H-1 NMR, MS and elemental analysis. Analgesic activity was evaluated by a modified Koster test. Seven compounds showed analgesic activities higher than that of acetylsalicylic acid. (C) 1999 Elsevier Science S.A. All rights reserved.