Analgesic activity of acylated 2-benzoxazolinone derivatives


GÖKHAN KELEKÇİ N., ERDOĞAN H., KANDİLCİ N. T. , Demirdamar R.

FARMACO, vol.54, pp.112-115, 1999 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54
  • Publication Date: 1999
  • Doi Number: 10.1016/s0014-827x(98)00111-6
  • Journal Name: FARMACO
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.112-115
  • Keywords: 2-benzoxazolinone, acylation, analgesic activity, 6-METHOXYBENZOXAZOLINONE, BENZOXAZOLINONE, MELATONIN

Abstract

Ten new benzoxazolinone derivatives having a disubstituted benzoyl group at the six position of the ring were synthesized by reacting 2-benzoxazolinone with aromatic carboxylic acids in the presence of polyphosphoric acid. The structure of the compounds were elucidated by IR,H-1 NMR, MS and elemental analysis. Analgesic activity was evaluated by a modified Koster test. Seven compounds showed analgesic activities higher than that of acetylsalicylic acid. (C) 1999 Elsevier Science S.A. All rights reserved.