Electron microscopic evaluation of anterior lens epithelium in patients with idiopathic congenital cataract

Tekin K., Erol Y. O., Inanc M., SARGON M. F., Can C. U., Polat S., ...Daha Fazla

INTERNATIONAL OPHTHALMOLOGY, cilt.38, sa.5, ss.2127-2132, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 5
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1007/s10792-017-0713-1
  • Dergi Adı: INTERNATIONAL OPHTHALMOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2127-2132
  • Hacettepe Üniversitesi Adresli: Evet

Özet

PurposeTo investigate the ultrastructure of the lens epithelial cells (LECs) in patients with idiopathic congenital cataract.MethodsThis is a prospective interventional study. The anterior lens capsules (aLC: basement membrane and associated LECs) were taken from 16 eyes of 12 consecutive patients who were diagnosed as having idiopathic congenital cataracts. The aLCs were obtained from cataract surgery and prepared for transmission electron microscopy (TEM).ResultsSome significant ultrastructural changes were observed in all aLCs of the participants. The anterior LECs showed alterations in different areas which were partly cuboidal and partly squamous in shape. The LECs had euchromatic nucleus and included some vacuoles in the cytoplasms as a remarkable alteration. The sizes of these intraepithelial cell vacuoles were changeable.ConclusionsWe identified remarkable changes in LECs of the eyes with idiopathic congenital cataract by TEM. It can be assumed that oxidative damage may be associated with these ultrastructural changes in LECs of the eyes with idiopathic congenital cataracts.