Immunometabolism - The Role of Branched-Chain Amino Acids

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Yahsi B., GÜNAYDIN G.

FRONTIERS IN IMMUNOLOGY, cilt.13, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 13
  • Basım Tarihi: 2022
  • Doi Numarası: 10.3389/fimmu.2022.886822
  • Dergi Adı: FRONTIERS IN IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
  • Anahtar Kelimeler: immunometabolism, T cells, regulatory T cells (Tregs), branched-chain amino acids (BCAAs), branched-chain keto acids (BCKAs), tumor microenvironment, isoleucine, REGULATORY T-CELLS, FATTY-ACIDS, METABOLIC CHECKPOINT, ACRODERMATITIS DYSMETABOLICA, GLUCOSE-METABOLISM, CD36 EXPRESSION, BINDING PARTNER, IN-VIVO, ACTIVATION, MTORC1
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Immunometabolism has been the focus of extensive research over the last years, especially in terms of augmenting anti-tumor immune responses. Regulatory T cells (Tregs) are a subset of CD4(+) T cells, which have been known for their immunosuppressive roles in various conditions including anti-tumor immune responses. Even though several studies aimed to target Tregs in the tumor microenvironment (TME), such approaches generally result in the inhibition of the Tregs non-specifically, which may cause immunopathologies such as autoimmunity. Therefore, specifically targeting the Tregs in the TME would be vital in terms of achieving a successful and specific treatment. Recently, an association between Tregs and isoleucine, which represents one type of branched-chain amino acids (BCAAs), has been demonstrated. The presence of isoleucine seems to affect majorly Tregs, rather than conventional T cells. Considering the fact that Tregs bear several distinct metabolic features in the TME, targeting their immunometabolic pathways may be a rational approach. In this Review, we provide a general overview on the potential distinct metabolic features of T cells, especially focusing on BCAAs in Tregs as well as in their subtypes.