Multi-layered functional membranes for periodontal regeneration: Preparation and characterization
MATERIALS LETTERS, vol.178, pp.256-259, 2016 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 178
- Publication Date: 2016
- Doi Number: 10.1016/j.matlet.2016.05.054
- Journal Name: MATERIALS LETTERS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.256-259
- Hacettepe University Affiliated: Yes
Abstract
Multi-layered biodegradable membranes (MLMs) were fabricated by combining electrospinning and solvent casting/particulate leaching methods. MLMs possess three layers of different functional properties; poly (caprolactone) (PCL)/nano-hydroxyapatite core layer and PCL/collagen, PCL/collagen-bone morphogenic protein 7 (BMP 7) outer layers on each side of the core layer. MC3T3-E1 cell culture tests showed that osteoblastic differentiation was enhanced on PCL/collagen BMP 7 layer. This facile method presents great potential for fabrication of multi-functional barrier membranes for periodontal regeneration as well as scaffolds possessing different properties to mimic complex extra cellular matrix structures with stable integrity. (C) 2016 Elsevier B.V. All rights reserved.