Evaluation of the Effects of Transforming Growth Factor-Beta 3 (TGF-beta 3) Loaded Nanoparticles on Healing in a Rat Achilles Tendon Injury Model


ÇETİK R. M. , Ciftci S. Y. , ARICA YEGİN B., BAYSAL İ., Dizakar S. O. A. , Elibol F. K. E. , ...More

AMERICAN JOURNAL OF SPORTS MEDICINE, 2022 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2022
  • Doi Number: 10.1177/03635465211073148
  • Journal Name: AMERICAN JOURNAL OF SPORTS MEDICINE
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EBSCO Education Source, Education Abstracts, EMBASE, MEDLINE, SportDiscus
  • Keywords: Achilles tendon, TGF-beta 3, PLGA-b-PEG, nanoparticle, TGF-BETA, GENE-EXPRESSION, STEM-CELLS, REPAIR, CHITOSAN, RUPTURE, MATRIX, DIFFERENTIATION, TISSUE, CHONDROGENESIS

Abstract

Background: Achilles tendon (AT) midsubstance injuries may heal suboptimally, especially in athletes. Transforming growth factor-beta 3 (TGF-beta 3) shows promise because of its recently discovered tendinogenic effects. Using poly(lactic-co-glycolic acid)-b-poly(ethylene glycol) (PLGA-b-PEG) nanoparticles (NPs) may enhance the results by a sustained-release effect.