Evaluation of the Effects of Transforming Growth Factor-Beta 3 (TGF-beta 3) Loaded Nanoparticles on Healing in a Rat Achilles Tendon Injury Model
AMERICAN JOURNAL OF SPORTS MEDICINE, cilt.50, sa.4, ss.1066-1077, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 50 Sayı: 4
- Basım Tarihi: 2022
- Doi Numarası: 10.1177/03635465211073148
- Dergi Adı: AMERICAN JOURNAL OF SPORTS MEDICINE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EBSCO Education Source, Education Abstracts, EMBASE, MEDLINE, SportDiscus
- Sayfa Sayıları: ss.1066-1077
- Anahtar Kelimeler: Achilles tendon, TGF-beta 3, PLGA-b-PEG, nanoparticle, TGF-BETA, GENE-EXPRESSION, STEM-CELLS, REPAIR, CHITOSAN, RUPTURE, MATRIX, DIFFERENTIATION, TISSUE, CHONDROGENESIS
- Hacettepe Üniversitesi Adresli: Evet
Özet
Background: Achilles tendon (AT) midsubstance injuries may heal suboptimally, especially in athletes. Transforming growth factor-beta 3 (TGF-beta 3) shows promise because of its recently discovered tendinogenic effects. Using poly(lactic-co-glycolic acid)-b-poly(ethylene glycol) (PLGA-b-PEG) nanoparticles (NPs) may enhance the results by a sustained-release effect.