Evaluation of the Effects of Transforming Growth Factor-Beta 3 (TGF-beta 3) Loaded Nanoparticles on Healing in a Rat Achilles Tendon Injury Model

ÇETİK R. M., Ciftci S. Y., ARICA YEGİN B., BAYSAL İ., Dizakar S. O. A., Elibol F. K. E., ...More

AMERICAN JOURNAL OF SPORTS MEDICINE, vol.50, no.4, pp.1066-1077, 2022 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 4
  • Publication Date: 2022
  • Doi Number: 10.1177/03635465211073148
  • Journal Name: AMERICAN JOURNAL OF SPORTS MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EBSCO Education Source, Education Abstracts, EMBASE, MEDLINE, SportDiscus
  • Page Numbers: pp.1066-1077
  • Keywords: Achilles tendon, TGF-beta 3, PLGA-b-PEG, nanoparticle, TGF-BETA, GENE-EXPRESSION, STEM-CELLS, REPAIR, CHITOSAN, RUPTURE, MATRIX, DIFFERENTIATION, TISSUE, CHONDROGENESIS
  • Hacettepe University Affiliated: Yes

Abstract

Background: Achilles tendon (AT) midsubstance injuries may heal suboptimally, especially in athletes. Transforming growth factor-beta 3 (TGF-beta 3) shows promise because of its recently discovered tendinogenic effects. Using poly(lactic-co-glycolic acid)-b-poly(ethylene glycol) (PLGA-b-PEG) nanoparticles (NPs) may enhance the results by a sustained-release effect.