Evaluation of the Effects of Transforming Growth Factor-Beta 3 (TGF-beta 3) Loaded Nanoparticles on Healing in a Rat Achilles Tendon Injury Model

ÇETİK R. M., Ciftci S. Y., ARICA YEGİN B., BAYSAL İ., Dizakar S. O. A., Elibol F. K. E., ...Daha Fazla

AMERICAN JOURNAL OF SPORTS MEDICINE, cilt.50, sa.4, ss.1066-1077, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1177/03635465211073148
  • Dergi Adı: AMERICAN JOURNAL OF SPORTS MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EBSCO Education Source, Education Abstracts, EMBASE, MEDLINE, SportDiscus
  • Sayfa Sayıları: ss.1066-1077
  • Anahtar Kelimeler: Achilles tendon, TGF-beta 3, PLGA-b-PEG, nanoparticle, TGF-BETA, GENE-EXPRESSION, STEM-CELLS, REPAIR, CHITOSAN, RUPTURE, MATRIX, DIFFERENTIATION, TISSUE, CHONDROGENESIS
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Achilles tendon (AT) midsubstance injuries may heal suboptimally, especially in athletes. Transforming growth factor-beta 3 (TGF-beta 3) shows promise because of its recently discovered tendinogenic effects. Using poly(lactic-co-glycolic acid)-b-poly(ethylene glycol) (PLGA-b-PEG) nanoparticles (NPs) may enhance the results by a sustained-release effect.